Engadget states, “Scientists have discovered a way of counteracting proteins that cause Alzheimer’s-like symptoms including memory loss. Researchers at Washington University in St. Louis, Missouri focus on tau protein tangles.” in an article about Dr. Miller’s 2017 STM publication.
Category: Dementia
Scientists Stop and Reverse Alzheimer’s-Related Brain Damage in Mice (Links to an external site)
A news release by MNT examines Dr. Miller’s 2017 STM publication. “The team studied the effects of the synthetic molecules on crab-eating macaques. They administered two doses of antisense oligonucleotides or two doses of a placebo, 1 week apart, directly into the cerebrospinal fluid – as one would when treating humans. The trial revealed that, in monkeys […]
Molecule Throws Roadblock in Alzheimer’s Path (Links to an external site)
An article by New Atlas describing Dr. Miller’s STM work states, “When it comes to the drama of Alzheimer’s disease, the compound in the starring role as the villain is tau. It’s a protein that normally helps our neurons function properly, but one that can clump together into plaques that damage brain cells. Now researchers have […]
New DNA-Like Drugs Show Promise in Treating Alzheimer’s (Links to an external site)
An article by Scientific American describes Dr. Miller’s Science Translational Medicine publication. “The small molecules cleared and prevented tau buildup in mice and monkeys.”
Antisense Oligos Tango with Tau Transcripts to Reverse Tauopathy (Links to an external site)
In an article about Dr. Miller’s newest Science Translational Medicine publication, ALZFORUM writes, “In collaboration with the pharmaceutical company Ionis in Carlsbad, California, Timothy Miller and his colleagues at Washington University in St. Louis designed a potent ASO that shuts down human tau gene expression in transgenic mouse models.”