The Miller Laboratory is dedicated to understanding neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and dementias in order to develop new, effective, and safe treatments. We focus on translational neuroscience, new therapeutic approaches for neurodegenerative diseases, and precision medicine.
WHAT WE DO
ALS Research
The Miller Lab seeks to understand the pathogenesis of ALS with basic studies focused on SOD1, C9ORF72, TBK-1, miRNA, protein misfolding, protein kinetics, and genetic modifiers of disease. We employ RNA-targeted therapeutic strategies, mainly using antisense oligonucleotides.
Dementia Research
The Miller Lab studies how the various isoforms of the protein tau affect neurodegeneration. We employ RNA-targeted therapeutic strategies using antisense oligonucleotides to develop therapies for dementias involving the tau protein as well as for TREM-2.
LATEST NEWS
Promising Results for Investigational Treatments for Inherited ALS (Links to an external site)
Tofersen demonstrates positive results in Phase I/II trial for amyotrophic lateral sclerosis (Links to an external site)
Experimental drug shows promising results for rare form of ALS (Links to an external site)
HOW YOU CAN HELP
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